All those who took the mark will be stricken with a plague-like disease producing festering sores. I can see it being passed off as an unfortunate circumstance of the technique used to make the mark. The first bowl of wrath has been poured out.
The entire sea will be stricken with a reddish pollution that will kill everything still left in it after the earlier judgments. This may be something akin to red tide run amok. The second bowl of wrath has been poured out.
The pollution spreads to fresh water. The third bowl of wrath has been poured out.
The sun will suddenly become much more active, perhaps a solar flare and a coronal mass ejection, and scorch the inhabitants of earth with intense heat and sunburns. Their reaction will be to curse God. Evidently, their worship of the Antichrist will not preclude them from having at least some reckoning of the true God. The fourth bowl of wrath has been poured out.
Likely the effects of a solar flare from the increased activity of the sun, something will strike Bergama, Turkey and throw the Antichrist's kingdom into darkness. Computer systems will crash, power will go offline, communications will cease, and his kingdom (the three broken off horns) will literally and figuratively be in the dark. This is a local, specific event rather than a global incident. His people's reaction: blasphemy. The fifth bowl of wrath has been poured out.
The Euphrates River, which had been ground zero for volcanism of sixth trumpet, finally dries up all together. It provides troops amassing in the east unhindered traverse to Israel. I believe the troops were originally moving to confront and perhaps unseat the Antichrist, but he, the Pope, and the Devil deftly spin a tale which unites those troops under his banner and against the invasion he is expecting (from outer space, I think). He directs them, along with others from other places, to the Jezreel Valley, near Megiddo. The sixth bowl of wrath has been poured out.
A global earthquake, the largest such event that will ever occur, will shake every city throughout the world. As a result, Jerusalem will be divided into three and Rome turned to ashes. Islands will be inundated and mountains crumble in landslides. Although the related signs of volcanic or asteroidal activity are not mentioned, a rain of large hail falls upon the earth, which makes me wonder if this is yet another aspect of the earlier strikes (i.e. a comet breaking up and hitting earth piecemeal). The seventh bowl of wrath has been poured out.
At that time, Jesus will burst through the skies, with all the saints raptured before in tow behind him. He captures the Antichrist and the Pope and tosses them into the Lake of Fire, which will have been formed at that time. All the amassed troops are killed, their bodies left to the birds. The Devil is bound and locked in the Abyss (and I would conclude all the demons with him).
Jesus has returned to earth, the saints with him, and he will rule with a rod of iron and the saints will reign with him.
Yet to come... the Millennium and Beyond